Be aware that SmoothQuick simply tunes the current PIDs more towards smooth or quick. It is best (but not required) to use a different tuning if you change the weight (add a camera), props, number of lipo cells; so generally thrust or weight changes.
That said, you can tune it with the heavier/slower setup and always use that. It will just have a little slower response than it could have when actually flying the light setup. If you tune with the lighter/powerful setup and then add weight (a camera), you might get oscillations, just like tuning with fast ESCs and then changing to slow ESCs would give you oscillations.
The PID banks feature is great for setups needing heavy vs. light PIDs. Tune with camera, set SQ smoother, copy it (default is that it is written to bank #3) to bank #1. Tune it without camera, set SQ quicker (if that is what you want), copy it to bank #2. Set up your FMS to use the different banks (#1 and #2) with different switch positions. You now have an FMS switch position for stunt/light and another one for camera/heavy. SQ still modifies bank #3. You probably don't want SQ enabled after setting this up. SmoothQuick uses the single currently stored (most recent tune) AT math data. If you did the 'light' tune last (so 'light' AT math data is current) then any PIDs written by SQ will be with 'light' settings.
If you still want SQ permanent (with two tunes stored in different banks), the way to handle that is to do the tune that you want to play with last (stunt/light in this example). Then change the AT output bank (in System->Settings->SystemIdentSettings) to point to the PID bank where you have that (stunt/light is in #2 in this example). In that case you will only see the effect of the knob while flying stunt/light. (Or just use PID bank #3 for stunt/light. No copy bank for stunt/light. No changing the AT output bank.)