Old thread, but generally not.
You problem could be incorrectly set output type (PwmSync / OneShot / etc), bad ESC, bad motor, bad connector, bad FC output. Move things around to find what is the bad thing. Bad FC output can be worked around by moving ESC connector to a different output, and changing from 1-1 2-2 3-3 4-4 x-x to x-x 2-2 3-3 4-4 5-1 (I forget exactly what it looks like).