It is uncommon, but it has been done. I have not heard of anyone doing it in a long time.
There are safety issues, arming issues, etc.
After getting if flying in rate mode, take props off, look into changing System->Settings->MixerSettings->Mixer#Type from Motor to ReversableMotor (yes, it is spelled wrong.
) When you get it working (esc/motor neutrals, arming, disarming, safety) OK with props off, you might try flying it.
Let us know how it goes.