Hey Charley,
TBO ==Tail blow out, what we called it on stock Blade mcpx. I have not seen it on my 250s. Do you have enough throw on the tail rotor? Are the maximum and minimums sufficient to get yaw control? Once you get the yaw neutral set pretty close you can: move the servo, adjust the push rod or I believe--use some trim. I just use yaw neutral without changing the other adjustments. Know that moving the servo or changing the pushrod also moves the endpoints.
I have learned that higher throttle settings require smaller PI numbers. Try tuning with a flat throttle curve to eliminate one of the two variables you're dealing with: pitch AND throttle. I start maybe at 40% , get it stable and then raise the throttle, readjust the PIDs and raise the throttle again. I am at 70% with both of mine now and am trying to learn a ratio between headspeed and PIDs.
What mode are you using? I fly mostly in Rate, Rate, AxisLock.
Are you in calm air? Do you try different TX flight modes to compare PIDs?
good luck,
Dave